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primidone will lower the extent or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.iloperidone will increase levels of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Iloperidone is a time-dependent CYP3A inhibitor and could bring about improved plasma